An anonymous scientist talking to Wired tells us how shutting down the United States government even for 1 day destroys most live biomedical research experiments:
"Scientists are hardworking people. They work long hours, on weekends,
and they do that because it’s necessary. The schedules they follow
aren’t like an industrial plant’s. If you interrupt them, they can’t
pick up and start again. It’s an enormous waste of money and resources
to interrupt this and have it abandoned."
Then he goes on to talk about "mercy killing" their lab animals and it gets a bit creepy, but he ends with this gem:
"It’s ironic that factions with names like Tea Party and Patriot engage in
anti-American behavior: shutting down the government because they don’t
agree with a vote passed by the majority."